Compositions and methods of treatment using nicotinamide mononucleotide
AssigneeWashington University
InventorsShin-ichiro Imai, Alessia Grozio
Life of this patent
Estimating the term…
Abstract
Various methods and compositions for treating age-associated conditions and other medical conditions, such as muscle diseases, type 2 diabetes, and/or obesity are described. Methods of enhancing cellular uptake of NMN and stimulating NAD+ production are further described. Various mammalian cells and mammalian cell lines are described including those comprising a cDNA encoding a Slc12a8 protein. Gene therapy vectors comprising a nucleic acid encoding Slc12a8 and non-human animals comprising an inactivating mutation in a Slc12a8 gene are also disclosed. Also described are methods for screening a candidate compound to identify compounds that promote NMN transport.
Claims4
A pharmaceutical composition comprising nicotinamide mononucleotide (NMN) and an agonist of an NMN transporter a compound of structure (I)
- or a pharmaceutically acceptable salt thereof, wherein R is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, n-hexyl, n-octyl, 2-chloroethyl, 2-hydroxyethyl, 3-hydroxypropyl, 2-methoxyethyl, 2-butoxyethyl, carbamoylmethyl, 1-carbamoylethyl, 2-dimethylaminoethyl, 3-aminopropyl, tetrahydrofurfuryl, benzyl, phenoxyethyl, p-chlorophenyl, and p-nitrophenyl.
Dependencies are inferred from the claim text.