Coumarin-modified androgens for the treatment of prostate cancer
AssigneesHealth Research, Inc., University of Kentucky Research Foundation
InventorsJames L. Mohler, Michael V. Fiandalo, David Watt, Vitaliy Sviripa
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Abstract
Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.
Claims23
A compound having the following structure:
- wherein
- R1 is hydrogen or an alkyl group;
- L1 is a linking group, L2 is optional and is a linking group,
- Z is an end group comprising (a) a substituted or unsubstituted coumarin group or
- (b)
- or a substituted variant thereof, and R2 is an alkyl group or hydrogen.
Dependencies are inferred from the claim text.