Stopper device, medicament container, and method for mixing two substances in a medicament container

A medicament container, comprising a base body (47) and a stopper device (1) for sealing off the medicament container (45) with a stopper element (3),

• wherein the stopper device (1) is embodied to seal off the medicament container (45) in an axial direction of a center axis (M) of the medicament container (45),
• wherein the stopper device (1) is at least partially insertable into the medicament container (45) and in an intended installation position in the medicament container (45) the stopper element (3) is displaceable along the center axis (M) of the medicament container (45),
• wherein the stopper device (1) has a retention region (23) with at least one retention means (5),
• wherein, in a first functional state of the stopper device (1), a closure element (7) is releasably retained in a fixed position relative to the stopper element (3) by means of the retention means (5), in such a way that a cavity (29) is formed between the closure element (7) and the stopper element (3),
• wherein the stopper device (1) is arranged moved into the medicament container (45) such that the stopper element (3) seals off a proximal end (49) of the medicament container (45) with respect to a chamber (51) of the base body (47),
• wherein the chamber (51) is delimited in a radial direction by the inner wall (53) of the base body (47) and in a distal direction by an outlet opening (55) of the base body (47) and/or a closure cap (57), and
• wherein the stopper element (3) is elastic,
• wherein it is deformable by means of the projection (73) of the dispensing device (67), and
• wherein the discharge projection (63) of the stopper element (3) has a greater strength in the axial direction than the pressure required to move the closure element (7).

A method for mixing two substances (31, 59) stored separately from one another in terms of flow in a medicament container (45), the medicament container (45) with a base body (47) and a stopper device (1) for sealing off a medicament container (45), with a stopper element (3),

• wherein the stopper device (1) is embodied to seal off the medicament container (45) in an axial direction of a center axis (M) of the medicament container (45),
• wherein the stopper device (1) is at least partially insertable into the medicament container (45) and in an intended installation position in the medicament container (45) the stopper element (3) is displaceable along the center axis (M) of the medicament container (45),
• wherein the stopper device (1) has a retention region (23) with at least one retention means (5),
• wherein, in a first functional state of the stopper device (1), a closure element (7) is releasably retained in a fixed position relative to the stopper element (3) by means of the retention means (5), in such a way that a cavity (29) is formed between the closure element (7) and the stopper element (3),
• wherein the stopper device (1) is arranged moved into the medicament container (45) such that the stopper element (3) seals off a proximal end (49) of the medicament container (45) with respect to a chamber (51) of the base body (47),
• wherein the chamber (51) is delimited in a radial direction by the inner wall (53) of the base body (47) and in a distal direction by an outlet opening (55) of the base body (47) and/or a closure cap (57),
• wherein a first substance (31) of the two substances (31,59) is arranged in the cavity (29) of the stopper device (1) and a second substance (59) of the two substances (31,59) is arranged in the chamber (51) of the base body (47),
• wherein the stopper element (3) is acted upon with a force in the distal direction, wherein the fluidic separation of the two substances (31, 59) is eliminated, characterized in that the stopper device (1), is deformed, at least partially, due to the distal force application, such that the closure element (7) is moved out of a retention position,
• wherein the stopper element (3) is displaced in the distal direction,
• wherein the fluidic separation of the two substances (31, 59) is eliminated,
• wherein the retention region (23) relaxes radially during a distal displacement of the stopper device (1), and
• wherein a retention of the closure element (7) in the retention position is released.