Method and device for providing offset model based calibration for analyte sensor

A method of determining a non-attenuated sensitivity of a glucose sensor positioned in fluid contact with interstitial fluid, comprising:

• generating, by the glucose sensor, electrical signals indicative of a glucose level in the interstitial fluid;
• obtaining, by a data processing unit operatively coupled with the glucose sensor, a plurality of data points from the signals generated by the glucose sensor, wherein the data processing unit comprises one or more processors, a transceiver to transmit data to a receiving unit, and a memory storing instructions which when executed by the one or more processors enable the data processing unit to perform specified operations;
• pairing, by the data processing unit, the plurality of data points with reference data from a reference data source to form a plurality of pairs;
• forming, by the data processing unit, a plurality of groups each including one or more of the plurality of pairs;
• determining, by the data processing unit, a representative sensitivity of the glucose sensor for each of the plurality of groups, wherein the representative sensitivity of a group is based on corresponding sensitivities of the one or more of the plurality of pairs included in the group;
• selecting, by the data processing unit, one or more of the representative sensitivities based on the selected representative sensitivities satisfying one or more criteria;
• determining, by the data processing unit, the non-attenuated sensitivity based on a weighted average of the selected representative sensitivities;
• applying, by the data processing unit, the determined non-attenuated sensitivity to the plurality of data points obtained from the glucose sensor to estimate a glucose level;
• and
• causing, by the data processing unit, output of an alarm to a user based on the estimated glucose level.