Synchronization of ion generation with cycling of a discontinuous atmospheric interface
AssigneePurdue Research Foundation
InventorsRobert Graham Cooks, Guangtao Li, Guangming Huang, Jason Duncan, Xin Li, Ewa Sokol, Xin Yan
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Abstract
The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
Claims8
A method for monitoring a reaction in real-time, the method comprising:
- providing an online reaction monitoring system that comprises a reaction vessel that comprises an outlet port;
- a channel that extends from within the outlet port;
- an electrode operably associated with a distal end of the channel;
- and a mass spectrometer;
- selecting a solvent that is compatible as both a reaction solvent and an ionization solvent;
- conducting a reaction in the solvent in the reaction vessel;
- flowing a portion of the solvent from the reaction vessel through the channel;
- generating ions of one or more analytes in the solvent by applying an electrical potential to a distal end of the channel via the electrode;
- using the flowed portion of the solvent from the vessel as the ionization solvent;
- and
- analyzing the ions in the mass spectrometer, thereby monitoring the reaction in real-time.
Dependencies are inferred from the claim text.