Oligonucleotide conjugate with high hybridization performance and use thereof
AssigneeDaan Gene Co., Ltd.
InventorsXiwen Jiang, Ling He, Shilong Lan
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Abstract
The present invention provides an oligonucleotide conjugate with high hybridization performance and use thereof. The oligonucleotide conjugate of the present invention can be used as a probe for nucleic acid detection, the oligonucleotide conjugate of the present invention can be used to design probes more flexibly, and the conservative regions are more accessible. The specificity of the probe is better, and the fluorescence value of the probe can be significantly improved, the fluorescence background is significantly reduced, and the sensitivity of the probe is greatly improved.
Claims14
An oligonucleotide conjugate, wherein the structure of the oligonucleotide conjugate is shown in the following Formula I:
- R—N-Q-D, I
- wherein R is an optional fluorescent group, N is an oligonucleotide unit, Q is a quenching group, and D is a cationic unit.
Dependencies are inferred from the claim text.