Respiratory and sweat gland ionocytes
AssigneesThe Broad Institute, Inc., The General Hospital Corporation, Massachusetts Institute of Technology
InventorsJayaraj Rajagopal, Aviv Regev, Moshe Biton, Adam Haber, Daniel Montoro, Orit Rozenblatt-Rosen
Life of this patent
Estimating the term…
Abstract
Provided herein are methods and compositions for identifying ionocytes from respiratory epithelial cells, and uses of such cells for treatment of inflammatory lung disease. Also provided herein are methods and compositions for modulating respiratory tract epithelial cell proliferation, differentiation, maintenance, and/or function.
Claims8
A method for increasing expression of CFTR in epithelial ionocytes, the method comprising delivering in vivo to a subject in need thereof one or more modulating agents comprising an adenovirus viral vector (AAV) comprising a polynucleotide sequence encoding FOXI1, wherein delivery of the polynucleotide sequence encoding FOXI1 increases the expression of FOXI1 and CFTR in the epithelial ionocytes.
Dependencies are inferred from the claim text.