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US 12,331,310 B2Granted
Cell membrane penetrating conjugates for gene editing
AssigneeCygenica Limited
InventorNusrat Sanghamitra
Life of this patent
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Abstract
A genome-editing complex for modifying a target polynucleotide comprising a recombinant β helical protein linked to either one or more molecules of a genome-editing system or a plasmid encoding for one or more molecules of a genome-editing system, wherein the β helical protein length is in the range of from 5 nm to 25 nm, and width is in the range of from 1 nm to 5 nm.
Claims24
A genome-editing complex for modifying a target polynucleotide comprising a recombinant β helical protein, represented by a sequence selected from the group consisting of SEQ ID NO:
- 1, SEQ ID:
- 2, SEQ ID:
- 3, SEQ ID:
- 4, SEQ ID:
- 5, SEQ ID:
- 6, SEQ ID:
- 7, SEQ ID:
- 8, SEQ ID:
- 9, SEQ ID:
- 10, SEQ ID:
- 11, SEQ ID:
- 12, and combinations thereof, wherein the recombinant β helical protein is linked to a component selected from the group consisting of:
- one or more molecules of a genome-editing system and a plasmid that encodes one or more molecules of a genome-editing system, wherein the recombinant β helical protein length is in the range of from 5 to 25 nanometers, and width is in the range from 1 to 5 nanometers.
10 more elements
Dependencies are inferred from the claim text.