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US 12,331,095 B2Granted
Inducible T cell receptors and uses thereof
AssigneeMedigene Immunotherapies GmbH
InventorsSlavoljub Milosevic, Adriana Turqueti Neves, Kristina Schoedel, Alexander Schmidt
Life of this patent
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Abstract
Combinations comprising one or more nucleic acid molecules comprising a nucleic acid sequence A encoding for a TCR alpha chain linked to a dimerization domain, and a nucleic acid sequence B encoding for a TCR beta chain linked to a dimerization domain, as well as proteins encoded by such nucleic acid molecules and corresponding uses and methods.
Claims19
A combination comprising one or more nucleic acid molecules, said one or more nucleic acid molecules comprising:
- (a) a nucleic acid sequence A, comprising
- (i) a nucleic acid sequence encoding an amino acid sequence being at least 90% identical to SEQ ID NO:
- 2 and optionally comprising at least one amino acid substitution compared to the amino acid sequence of SEQ ID NO:
- 2 selected from the group consisting of T44A and T47A, and
- (ii) a nucleic acid sequence encoding an inducible dimerization domain linked to, and downstream of, said nucleic acid sequence of (a)(i);
- and
- (b) a nucleic acid sequence B, comprising
- (i) a nucleic acid sequence encoding an amino acid sequence being at least 90% identical to SEQ ID NO:
- 4 and comprising at least one amino acid substitution compared to the amino acid sequence of SEQ ID NO:
- 4 selected from the group consisting of K4V, N5P, Y37K, L63A, S77A and R79A, and
- (ii) a nucleic acid sequence encoding an inducible dimerization domain linked to, and downstream of, said nucleic acid of (b)(ii), wherein said dimerization domain corresponds to the dimerization domain of (a)(ii),
- wherein said amino acid sequence of (a)(i) comprises at least one amino acid substitution compared to SEQ ID NO:
- 2.
10 more elements
Dependencies are inferred from the claim text.