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US 12,331,092 B2Granted
Leucine-rich ALPHA2 glycoprotein composition
AssigneesSekisui Medical Co., Ltd., National Institutes of Biomedical Innovation, Health and Nutrition
InventorsShigeo Takayama, Tetsuji Naka, Satoshi Serada
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Abstract
An object is to provide a leucine-rich α2 glycoprotein composition comprising leucine-rich α2 glycoprotein and having excellent preservation stability. The object can be achieved by a leucine-rich α2 glycoprotein composition comprising leucine-rich α2 glycoprotein and having a pH of 7.0 to 9.3.
Claims10
A leucine-rich α2 glycoprotein solution, comprising:
- leucine-rich α2 glycoprotein;
- a preservative;
- a glycoprotein other than LRG, or a peptide;
- a non-ionic surfactant;
- a buffer;
- a metal salt;
- and
- water,
- wherein pH of the solution is 7.8 to 9.0,
- concentration of the metal salt of the solution is 300 mM to 600 mM,
- 90% or more of the leucine-rich α2 glycoprotein contained in the solution containing the leucine-rich α2 glycoprotein is maintained without being decomposed or without a structural change for 29 days at 37° C., and
- said solution is suitable for use as a calibration sample solution for measuring leucine-rich α2 glycoprotein.
9 more elements
Dependencies are inferred from the claim text.