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US 12,331,067 B2Granted
Method for preparing 18F-BPA and intermediate
AssigneeNeuboron Medtech Ltd.
InventorsShi-hong Li, Jing He, Heng Yan, Fei Cai
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Abstract
A method for preparing 18F-BPA and an intermediate, by which high-purity 18F-BPA is obtained. The method simplifies the synthesis steps after 18F labeling, and is easy to operate and efficient.
Claims20
An intermediate I of the structure
- where R1 represents boric acid groups or substituents that is hydrolyzable to boric acid groups;
- R2 represents boric acid groups or substituents that is hydrolyzable to boric acid groups;
- R3 represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group;
- R4 represents hydrogen, an amino-protecting group, or an imino group combined with an amino group for protecting the amino group;
- and
- R5 represents hydrogen or a carboxyl-protecting group.
3 more elements
Dependencies are inferred from the claim text.