Compounds suitable for the treatment and prophylaxis of muscle wasting and other conditions
OwnerVolker Adams, Siegfried Labeitinventors
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Abstract
The present invention relates to a compound of the general formula I and the pharmaceutically acceptable salts thereof; where the variables are as defined in the claims and the description. The invention also relates to the compounds of formula I for use in the treatment or prophylaxis of muscle wasting conditions, of skeletal or cardial muscle atrophy, of conditions, in particular of myopathies, which are associated with an increased Muscle RING Finger 1 (MuRF1) expression and of other conditions; to the compounds of formula I for use as a medicament; to a pharmaceutical composition comprising at least one compound of formula I and to a method for treating said conditions.
Claims22
A compound of the general formula I
- wherein
- R1 is hydrogen or a group —CH2R1a, where R1a is selected from the group consisting of hydrogen, C1-C3-alkyl, phenyl, where phenyl is unsubstituted or may carry 1, 2 or 3 radicals independently selected from halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl and C1-C3-alkoxy;
- and a 5- to 10-membered heteroaromatic ring containing 1 to 4 heteroatoms or hetero-groups independently selected from the group consisting of N, NRc, O and S as ring member, where the 5- to 10-membered heteroaromatic ring is unsubstituted or may carry 1, 2 or 3 radicals R7;
- R2 is selected from the group consisting of hydrogen, methyl and fluorinated methyl;
- R3 is selected from the group consisting of hydrogen, methyl and fluorinated methyl;
- R4 is selected from the group consisting of hydrogen and C1-C4-alkyl;
- each R5 is independently selected from the group consisting of halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy;
- each R6 is independently selected from the group consisting of halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy;
- each R7 is independently selected from the group consisting of halogen, cyano, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy and C1-C3-haloalkoxy;
- X1 is NRa or O;
- X2 is NRb, O or S;
- Y represents an oxygen atom or two hydrogen atoms;
- Ra, Rb, Rc are each independently selected from the group consisting of hydrogen and C1-C4-alkyl;
- a is 0, 1, 2, 3 or 4;
- and
- b is 0, 1, 2 or 3;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.