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US 12,330,138 B2Granted
Surface functionalised materials for sampling biological molecules
AssigneePaul Antonio Jones
InventorPaul Antonio Jones
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Abstract
The invention relates to materials, methods and devices useful for sampling biological molecules, including biomarkers and/or metabolites. In particular, the invention relates to surface functionalised xerogels and surface functionalised poly(dimethyl) siloxane (PDMS), devices comprising those materials, and methods of using the materials and devices for sampling, analysing or detecting biological molecules.
Claims20
A surface-functionalised xerogel comprising a functional group that selectively binds to a biological molecule from a subject,
- wherein the surface-functionalised xerogel is monolithic and configured to have a size and shape suitable for insertion into a body orifice, a body cavity, or a bodily tube, and for contacting a mucous membrane therein, thereby sampling the biological molecule from the subject, and
- wherein the shape of the surface-functionalised xerogel is substantially that of a cylinder, a rod, a disk, a sphere, a cone, or a frustocone.
A method for preparation of a surface-functionalised xerogel, the method comprising:
- surface functionalising the xerogel with:
- i. N-octadecyl methacrylate p(ODMA) by thiol-ene surface-initiated polymerisation (TSIP);
- ii. Mannose methacrylate by thiol-ene surface-initiated polymerisation (TSIP);
- or
- iii. an antibody or an antigen-binding fragment thereof by reacting a thiol xerogel with a heterobifunctional crosslinking compound and an antibody or an antigen-binding fragment thereof;
- and
- forming the surface-functionalised xerogel into a sampling device having a size and shape suitable for insertion into a body orifice, a body cavity, or a bodily tube, and for contacting a mucous membrane therein, thereby sampling a biological molecule from a subject,
- wherein the surface-functionalised xerogel is monolithic, and
- wherein the shape of the surface-functionalised xerogel is substantially that of a cylinder, a rod, a disk, a sphere, a cone, or a frustocone.
6 more elements
Dependencies are inferred from the claim text.