Drug delivery devices and methods for administering substances to a body cavity by heterogenous aerosolization

A device configured to deliver one or more substances within at least one body cavity of a subject, the device comprising:

• at least one vial comprising a predetermined volume Vsub [ml or mg] of said substances;
• said at least one vial having a fluid inlet and a fluid discharging outlet, the fluid discharging outlet having a diameter D [mm] and being configured for placement in proximity to said at least one body cavity;
• said fluid inlet configured by means of size and shape to interface in a sealable manner with at least one puncturing member, the at least one puncturing member being configured to pierce the fluid inlet upon coupling to the fluid inlet, thereby providing said one or more substances in a fluid communication, via at least one valve, with at least one chamber configured to accept pressurized fluid at a volume VPF [ml] and a pressure PPF [barg];
• said valve is commutable from a CLOSED CONFIGURATION to an OPEN CONFIGURATION within a period of time dT, the period of time dT being less than 500 milliseconds;
• wherein when the valve is in said OPEN CONFIGURATION, said pressurized fluid flows from said at least one chamber via said fluid inlet and entrains said one or more substances such that the pressurized fluid erupts via said fluid discharging outlet to within said at least one body cavity in the form of an aerosol;
• wherein a release time dTrelease of said Vsub [ml or mg] of said one or more substances and said VPF [ml] of said pressurized fluid is less than 500 milliseconds;
• wherein a composition of the aerosol exiting said fluid discharging outlet into said at least one body cavity forms a bi-modal spray pattern, the bi-modal spray pattern having a first plume angle of less than 25° in a first portion and a second plume angle of approximately 35°±10° in a second portion.