Acoustic driven drug delivery systems

A method of treating one or more of primary or secondary cancer, Parkinson's disease, and epilepsy, by delivering a therapeutic agent to a patient in need thereof, comprising:

• administering to a patient a therapeutic formulation comprising a therapeutic agent and liposomes with hollow gold nanostructures tethered to the liposomes;
• and
• applying a pulsed ultrasound signal to the liposomes in the patient's brain, whereby the pulsed ultrasound signal delivers a stepwise release of the therapeutic agent from the liposome composition, wherein the ultrasound signal has a frequency between about 200 kHz and 1 MHZ, and wherein the ultrasound signal's intensity is between about 0.01 and 10 W/cm2
• wherein when the disease treated is primary or secondary cancer, the therapeutic agent is an anti-cancer agent or an antineoplastic agent;
• wherein when the disease to be treated is Parkinson's disease, the therapeutic agent is an agent capable of treating Parkinson's disease;
• and
• wherein when the disease to be treated is epilepsy, the therapeutic agent is capable of treating epilepsy.