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US 12,329,771 B2Granted
Methods relating to lung cancer
AssigneeTrustees of Boston University
InventorsAna Brandusa Pavel, Joshua David Campbell, Marc Elliott Lenburg, Avrum Elliot Spira
Life of this patent
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Abstract
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by therapeutically increasing the level of those miRNAs.
Claims5
A method of treating lung cancer in a subject in need thereof, the method comprising administering to the subject:
- a) an agonist of at least 1 miRNA selected from the group consisting of:
- miR-324-5p;
- miR-769-3p;
- miR-618;
- miR-338-5p;
- miR-210;
- miR-450a-5p;
- miR-30b-5p;
- miR-450a-5p;
- miR-652-3p;
- miR-107;
- miR-887;
- miR-147b;
- miR-31-5p;
- miR-29c-5p;
- miR-324-3p;
- miR-345-5p;
- miR-450b-5p;
- miR-769-5p;
- miR-326;
- miR-940;
- miR-582-5p;
- miR-31-3p;
- miR-378i;
- miR-505-3p;
- miR-1249;
- miR-1260b;
- miR-3200-3p;
- miR-425-3p;
- miR-4791;
- miR-1296;
- and miR-4677-3p;
- or
- b) an inhibitor of at least 1 miRNA selected from the group consisting of:
- miR-375;
- miR-24-1-5p;
- miR-130b-5p;
- miR-183-5p;
- and miR-203a.
36 more elements
Dependencies are inferred from the claim text.