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US 12,329,766 B2Granted
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
OwnerBarbara Brooke Jenningsinventor
Life of this patent
Estimating the term…
Abstract
The present invention relates to prevention of congenital deformations. The invention further relates to cancer inhibition and prevention. The invention further relates to methods and compositions to modulate, antagonize, or agonize disparate signaling pathways that may converge to regulate patterning events and gene expression during prenatal development, postnatal development, and during development in the adult, organism. The invention also relates to activators or deactivators of pyruvate kinase M2 (PKM2) for the treatment, prevention, or amelioration of diseases related to PKM2 function.
Claims9
A method of treating a cancer, comprising
- administering an effective amount of a D-chiro-inositol compound to a subject in need thereof, thereby treating the cancer, wherein the cancer comprises ovarian, pancreatic, or breast cancer;
- and
- wherein the D-chiro-inositol compound is selected from the group consisting of:
- D-chiro-inositol 1,2,3,4-tetraphosphate,
- D-chiro-inositol 1,2,3,5-tetraphosphate,
- D-chiro-inositol 1,2,4,5-tetraphosphate,
- D-chiro-inositol 1,2,4,6-tetraphosphate,
- D-chiro-inositol 1,2,5,6-tetraphosphate,
- D-chiro-inositol 1,3,4,5-tetraphosphate,
- D-chiro-inositol 1,3,4,6-tetraphosphate,
- D-chiro-inositol 1,3,5,6-tetraphosphate,
- D-chiro-inositol 1,4,5,6-tetraphosphate,
- D-chiro-inositol 2,3,4,5-tetraphosphate,
- D-chiro-inositol 2,3,4,6-tetraphosphate,
- D-chiro-inositol 2,3,5,6-tetraphosphate,
- D-chiro-inositol 2,4,5,6-tetraphosphate,
- D-chiro-inositol 3,4,5,6-tetraphosphate,
- D-chiro-inositol 1,2,3,4,5-pentaphosphate,
- D-chiro-inositol 1,2,3,4,6-pentaphosphate,
- D-chiro-inositol 1,2,3,5,6-pentaphosphate,
- D-chiro-inositol 1,2,4,5,6-pentaphosphate,
- D-chiro-inositol 1,3,4,5,6-pentaphosphate,
- D-chiro-inositol 2,3,4,5,6-pentaphosphate,
- D-chiro-inositol 1,2,3,4,5,6-hexaphosphate,
- D-chiro-inositol 1,2,3,4,5-pentaphosphate-6-pyrophosphate,
- D-chiro-inositol 1,2,3,4,6-pentaphosphate-5-pyrophosphate,
- D-chiro-inositol 1,2,3,5,6-pentaphosphate-4-pyrophosphate,
- D-chiro-inositol 1,2,4,5,6-pentaphosphate-3-pyrophosphate,
- D-chiro-inositol 1,3,4,5,6-pentaphosphate-2-pyrophosphate,
- D-chiro-inositol 2,3,5,6-pentaphosphate-1-pyrophosphate,
- D-chiro-inositol 1,2,3-triphosphate-4,5-dipyrophosphate,
- D-chiro-inositol 1,2,3-triphosphate-4,6-dipyrophosphate,
- D-chiro-inositol 1,2,3-triphosphate-5,6-dipyrophosphate,
- D-chiro-inositol 1,2,4-triphosphate-3,5-dipyrophosphate,
- D-chiro-inositol 1,2,4-triphosphate-3,6-dipyrophosphate,
- D-chiro-inositol 1,2,4-triphosphate-5,6-dipyrophosphate,
- D-chiro-inositol 1,2,5-triphosphate-3,4-dipyrophosphate,
- D-chiro-inositol 1,2,5-triphosphate-3,6-dipyrophosphate,
- D-chiro-inositol 1,2,5-triphosphate-4,6-dipyrophosphate,
- D-chiro-inositol 1,2,6-triphosphate-3,4-dipyrophosphate,
- D-chiro-inositol 1,2,6-triphosphate-3,5-dipyrophosphate,
- D-chiro-inositol 1,2,6-triphosphate-4,6-dipyrophosphate,
- D-chiro-inositol 1,3,4-triphosphate-2,5-dipyrophosphate,
- D-chiro-inositol 1,3,4-triphosphate-2,6-dipyrophosphate,
- D-chiro-inositol 1,3,4-triphosphate-5,6-dipyrophosphate,
- D-chiro-inositol 1,3,5-triphosphate-2,4-dipyrophosphate,
- D-chiro-inositol 1,3,5-triphosphate-2,6-dipyrophosphate,
- D-chiro-inositol 1,3,5-triphosphate-4,6-dipyrophosphate,
- D-chiro-inositol 1,3,6-triphosphate-2,4-dipyrophosphate,
- D-chiro-inositol 1,3,6-triphosphate-2,5-dipyrophosphate,
- D-chiro-inositol 1,3,6-triphosphate-4,5-dipyrophosphate,
- D-chiro-inositol 1,4,5-triphosphate-2,3-dipyrophosphate,
- D-chiro-inositol 1,4,5-triphosphate-2,6-dipyrophosphate,
- D-chiro-inositol 1,4,5-triphosphate-3,6-dipyrophosphate,
- D-chiro-inositol 1,4,6-triphosphate-2,3-dipyrophosphate,
- D-chiro-inositol 1,4,6-triphosphate-2,5-dipyrophosphate,
- D-chiro-inositol 1,4,6-triphosphate-3,5-dipyrophosphate,
- D-chiro-inositol 1,5,6-triphosphate-2,3-dipyrophosphate,
- D-chiro-inositol 1,5,6-triphosphate-2,4-dipyrophosphate,
- D-chiro-inositol 1,5,6-triphosphate-3,4-dipyrophosphate,
- D-chiro-inositol 2,3,4-triphosphate-1,5-dipyrophosphate,
- D-chiro-inositol 2,3,4-triphosphate-1,6-dipyrophosphate,
- D-chiro-inositol 2,3,4-triphosphate-5,6-dipyrophosphate,
- D-chiro-inositol 2,3,5-triphosphate-1,4-dipyrophosphate,
- D-chiro-inositol 2,3,5-triphosphate-1,6-dipyrophosphate,
- D-chiro-inositol 2,3,5-triphosphate-4,6-dipyrophosphate,
- D-chiro-inositol 2,3,6-triphosphate-1,4-dipyrophosphate,
- D-chiro-inositol 2,3,6-triphosphate-1,5-dipyrophosphate,
- D-chiro-inositol 2,3,6-triphosphate-4,5-dipyrophosphate,
- D-chiro-inositol 2,4,5-triphosphate-1,3-dipyrophosphate,
- D-chiro-inositol 2,4,5-triphosphate-1,6-dipyrophosphate,
- D-chiro-inositol 2,4,5-triphosphate-3,6-dipyrophosphate,
- D-chiro-inositol 2,4,6-triphosphate-1,3-dipyrophosphate,
- D-chiro-inositol 2,4,6-triphosphate-1,5-dipyrophosphate,
- D-chiro-inositol 2,4,6-triphosphate-3,5-dipyrophosphate,
- D-chiro-inositol 2,5,6-triphosphate-1,3-dipyrophosphate,
- D-chiro-inositol 2,5,6-triphosphate-1,4-dipyrophosphate,
- D-chiro-inositol 2,5,6-triphosphate-3,4-dipyrophosphate,
- D-chiro-inositol 3,4,5-triphosphate-1,2-dipyrophosphate,
- D-chiro-inositol 3,4,5-triphosphate-1,6-dipyrophosphate,
- D-chiro-inositol 3,4,5-triphosphate-2,6-dipyrophosphate,
- D-chiro-inositol 3,5,6-triphosphate-1,2-dipyrophosphate,
- D-chiro-inositol 3,5,6-triphosphate-1,4-dipyrophosphate,
- D-chiro-inositol 3,5,6-triphosphate-2,4-dipyrophosphate,
- D-chiro-inositol 4,5,6-triphosphate-1,2-dipyrophosphate,
- D-chiro-inositol 4,5,6-triphosphate-1,3-dipyrophosphate,
- D-chiro-inositol 4,5,6-triphosphate-2,3-dipyrophosphate,
- D-chiro-inositol 1-phosphate-2,3,4-tripyrophosphate,
- D-chiro-inositol 1-phosphate-2,3,5-tripyrophosphate,
- D-chiro-inositol 1-phosphate-2,3,6-tripyrophosphate,
- D-chiro-inositol 1-phosphate-2,4,5-tripyrophosphate,
- D-chiro-inositol 1-phosphate-2,4,6-tripyrophosphate,
- D-chiro-inositol 1-phosphate-2,5,6-tripyrophosphate,
- D-chiro-inositol 1-phosphate-3,4,5-tripyrophosphate,
- D-chiro-inositol 1-phosphate-3,4,6-tripyrophosphate,
- D-chiro-inositol 1-phosphate-3,5,6-tripyrophosphate,
- D-chiro-inositol 1-phosphate-4,5,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,3,4-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,3,5-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,3,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,4,5-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,4,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-1,5,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-3,4,5-tripyrophosphate,
- D-chiro-inositol 2-phosphate-3,4,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-3,5,6-tripyrophosphate,
- D-chiro-inositol 2-phosphate-4,5,6-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,2,4-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,2,5-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,2,6-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,4,5-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,4,6-tripyrophosphate,
- D-chiro-inositol 3-phosphate-1,5,6-tripyrophosphate,
- and
- D-chiro-inositol 3-phosphate-4,5,6-tripyrophosphate,
- wherein the D-chiro-inositol compound is linked via a covalent bond to a folic acid molecule.
113 more elements
Dependencies are inferred from the claim text.