Methods and compositions for targeting retinoic acid for solid tumor immunotherapy
AssigneeThe Trustees of the University of Pennsylvania
InventorsMalay Haldar, Samirkumar Devalaraja
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Abstract
The present invention relates to compositions and methods comprising a retinoic acid receptor inhibitor, a retinoic X receptor inhibitor or an inhibitor of an enzyme in the retinoic acid biosynthesis pathway for treatment of a patient having a solid tumor. In some embodiments, the solid tumor is a sarcoma.
Claims17
A method for treating a patient having a solid tumor, the method comprising administering to the patient an effective amount of a retinoic acid receptor inhibitor, an immune checkpoint inhibitor, and an inhibitor of an enzyme in the retinoic acid biosynthesis pathway.
A composition comprising:
- a. a retinoic acid receptor inhibitor;
- b. an immune checkpoint inhibitor;
- and
- c. an inhibitor of an enzyme in the retinoic acid biosynthesis pathway.
Dependencies are inferred from the claim text.