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US 12,329,745 B2Granted
Methods and compositions for treating glucocorticoid excess
AssigneeSparrow Pharmaceuticals, Inc.
InventorDavid A. Katz
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Abstract
The disclosure provides a method of treatment for glucocorticoid excess in a patient in need thereof, comprising administering to the patient a pseudo-irreversible HSD-1 inhibitor.
Claims15
A method for treating diabetes and lowering intracellular cortisol level in a human patient with diabetes and an elevated level of cortisol, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, wherein the compound is:
- and
- wherein the therapeutically effective amount of the compound, or the pharmaceutically acceptable salt thereof, is about 1 mg to about 40 mg daily;
- wherein the treatment decreases the patient's hemoglobin A1c (HbA1c) levels compared to the patient's HbA1c levels before the compound is initially administered to the patient;
- and wherein the compound does not show tachyphylaxis for HSD-1 inhibition in human adipose tissue.
1 more element
Dependencies are inferred from the claim text.