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US 12,329,137 B2Granted
Method of preparing mouse model of herpes
AssigneeAjou University Industry-Academic Cooperation Foundation
InventorSeonghyang Sohn
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Abstract
A method of preparing a mouse model of herpes using a herpes simplex virus and hydrocortisone, and a mouse model of herpes prepared using the method are disclosed. The method makes it possible to obtain an animal model in which symptoms of herpes clearly appear. The obtained animal model can be widely used in the development of therapeutic agents for herpes simplex virus infection. A use of the mouse model in screening and developing a candidate therapeutic agent is also disclosed.
Claims5
A method of preparing a mouse model of herpes, the method comprising:
- (a) damaging a site of surface of a mouse, inoculating the damaged site with herpes simplex virus type 1 (HSV-1), and then rearing the mouse;
- and
- (b) injecting the reared mouse with hydrocortisone,
- wherein the injection of hydrocortisone to the mouse is performed every day for 3 to 10 consecutive days from the day after the inoculation with herpes simplex virus type 1 has been completed, and
- wherein an amount of hydrocortisone injected is 75 μg/day to 300 μg/day per average body weight of mice, said average body weight being 25 g.
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Dependencies are inferred from the claim text.