Method of diagnosis of the aesthetic qualities of the skin

A method for cosmetic treatment of a skin for which the esthetic qualities are degraded in a subject, wherein the degraded esthetic qualities are selected from the reduction in shine, appearance of a rough texture, or an increase in skin flaccidity in a subject, wherein the subject does not suffer from dermatological lesions or a dermatological pathology, said method comprising the following steps:

• a) measuring the level of expression of the gene encoding FLG2 in a skin sample from said subject;
• wherein the level of expression of the gene encoding FLG2 is determined by measuring the level of expression of the protein encoded by the gene;
• b1) determining that the level of expression of the gene encoding FLG2 measured in step a) is statistically lower than a reference value, wherein the reference value is about 166 ng/ml of FLG2;
• and
• c1) treating the skin of the subject with a statistically lower expression level than the reference value with a cosmetic composition suitable for treating rough texture of the skin of the subject;
• or
• b2) determining that the level of expression of the gene encoding FLG2 measured in step a) is statistically higher than a reference value, wherein the reference value is about 140 ng/ml of FLG2 for shine and wherein the reference value is about 82 ng/ml of FLG2 for the flaccidity;
• and
• c2) treating the skin of the subject with a statistically higher expression level than the reference value with a cosmetic composition suitable for treating a reduction in the shine and/or an increase in the flaccidity of the skin of the subject.