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US 12,326,449 B2Granted
Fibrinogen biological material detection sensor including an erythrocyte membrane covered metal nanoparticle and fabricating method thereof
AssigneeKorea University Research and Business Foundation, Sejong Campus
InventorsJin Sung Park, Seong Jae Jo, Joo Hyung Park, Won Seok Lee, Heon Jeong Lee, Dae Sung Yoon, Gyu Do Lee, In Su Kim
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Abstract
Provided is a biomaterial detection sensor. The biomaterial detection sensor comprises a substrate and a detection probe including a metal nanoparticle deposited on the substrate, and an erythrocyte membrane conformally covering the metal nanoparticle, wherein the detection probe may selectively react with fibrinogen.
Claims7
A biomaterial detection sensor comprising:
- a substrate;
- and
- a detection probe including a metal nanoparticle deposited on the substrate, and an erythrocyte membrane conformally covering the metal nanoparticle,
- wherein the detection probe sensitively reacts with fibrinogen,
- wherein the biomaterial detection sensor is configured to linearly sense the fibrinogen in a concentration range of 0.001 to 10 mg/mL, and
- wherein an amount of change in a surface plasmon resonance signal of the substrate that changes when the detection probe selectively reacts with the fibrinogen decreases linearly as the concentration of the fibrinogen decreases.
3 more elements
A method for fabricating a biomaterial detection sensor, comprising:
- preparing a substrate and a metal nanoparticle;
- depositing the metal nanoparticle on the substrate;
- extracting an erythrocyte membrane from an erythrocyte;
- and
- providing the erythrocyte membrane on the substrate where the metal nanoparticle is deposited, so as to form a detection probe including the metal nanoparticle on the substrate and the erythrocyte membrane conformally covering the metal nanoparticle,
- wherein the detection probe sensitively reacts with fibrinogen,
- wherein the biomaterial detection sensor is configured to linearly sense the fibrinogen in a concentration range of 0.001 to 10 mg/mL, and
- wherein an amount of change in a surface plasmon resonance signal of the substrate that changes when the detection probe selectively reacts with the fibrinogen decreases linearly as the concentration of the fibrinogen decreases.
5 more elements
Dependencies are inferred from the claim text.