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US 12,326,448 B2Granted
Compositions and methods for high-sensitivity immunoassays
AssigneeUniversity of Virginia Patent Foundation
InventorsLeon S. Farhi, Alexander L. Klibanov, Bruce D. Gaylinn
Life of this patent
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Abstract
Lanthanide chelate lipid nanoparticles, and methods of their synthesis and use are described. Biological molecules labeled with the lipid nanoparticles, useful in bioaffinity assays with improved sensitivities are also described.
Claims21
A lipid nanoparticle consisting of:
- a) a plurality of phospholipids with aliphatic chains with chain lengths ranging from C19 to C50, wherein each phospholipid is attached to linker moiety, wherein the linker moiety is attached to the phospholipid via a polyethylene glycol linker, wherein the polyethylene glycol linker is (—CH2—CH2—O)n, wherein n is an integer from 3-2000;
- and
- b) a plurality of phospholipids with aliphatic chains with chain lengths ranging from C19 to C50, wherein each phospholipid is attached to a lanthanide chelate, wherein the lanthanide chelate consists of:
- (i) a lanthanide ion selected from the group consisting of Eu3+, Tb3+, Sm3+, and Dy3+;
- and
- (ii) a chelating agent.
3 more elements
Dependencies are inferred from the claim text.