Solubilized apyrases, methods and use
AssigneeNovartis AG
InventorsAgostino Cirillo, Hilmar Ebersbach, Boerje Haraldsson, Thomas Huber, Guido Junge, Regina Link, Max Warncke, Chao Zou
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Abstract
Provided herein are solubilized apyrase polypeptides, nucleotides encoding such solubilized apyrase polypeptides, pharmaceutical compositions containing such solubilized apyrase polypeptides, therapeutic uses of such solubilized apyrase polypeptides. Also provided herein are methods useful for preventing or treating tissue damage, e.g., by administering a solubilized apyrase polypeptide or pharmaceutical composition thereof, and methods for producing such solubilized apyrase polypeptides.
Claims8
A solubilized human apyrase comprising an amino acid sequence selected from the group consisting of SEQ ID NO:
- 58, SEQ ID NO:
- 74, and SEQ ID NO:
- 229.
A pharmaceutical composition comprising a solubilized human apyrase and one or more pharmaceutically acceptable carriers, wherein the solubilized human apyrase comprises an amino acid sequence selected from the group consisting of SEQ ID NO. 58, SEQ ID NO. 74, and SEQ ID NO. 229.
Dependencies are inferred from the claim text.