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US 12,325,726 B2Granted
Organic compounds
AssigneeIntra-Cellular Therapies, Inc.
InventorsKimberly Vanover, Peng Li, Robert Davis, Yupu Qiao
Life of this patent
Estimating the term…
Abstract
The invention relates to particular prodrugs and analogs of (3α,5α)-3-hydroxy-21-(1H-imidazol-1-yl)-3-methoxymethyl)-pregnan-20-one, in free or pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use as sedatives, hypnotics, anxiolytics, and/or anesthetics, and methods for treatment of depression, anxiety, insomnia, epilepsy, and other central nervous system disorders, as well as to combinations with other agents.
Claims28
A compound of a Formula I:
- wherein:
- X is selected from H, —(C═O)—Ra, —CH2—(C═O)—O—Ra, and —CH2—(C═O)—N(Ra)(Rb);
- R1 is selected from CH3, CDH2, CD2H and CD3;
- each of R2 to R9 is independently selected from H and D;
- Ra and Rb are independently selected from H, C1-20alkyl, and C1-4alkyl-aryl;
- in free or pharmaceutically acceptable salt form,
- provided that if R1 is CH3 and R2 to R9 are all H, then X is selected from —(C═O)—Ra, —CH2—(C═O)—O—Ra, and —CH2—(C═O)—N(Ra)(Rb).
4 more elements
Dependencies are inferred from the claim text.