US 12,325,720 B2 · Ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP1) inhibitors and uses thereof

Ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP1) inhibitors and uses thereof

Assignee1cBio, Inc.

InventorsBrahmam Pujala, Amantullah Ansari, Shreya Sapra, Pradeep S. Jadhavar, Dhananjay Pendharkar, Sreekanth A. Ramachandran, Uzma Saeed, Abhinandan Danodia, Farha Khan, Sagar Patni, Sanjeev Soni, Ashu Gupta, Sarvajit Chakravarty, Balaji Dashrath Sathe

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Abstract

The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

Claims11

Dependent claims

A compound selected from

or a pharmaceutically acceptable salt thereof.

Dependencies are inferred from the claim text.

Facts

Application

18/743,025Filed 13 Jun 2024 · continuation

Priority

30 Oct 2020

Published

US 2024/0352046 A124 Oct 2024

Granted

10 Jun 2025

Term ends

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Classification12 codes

C07F 5/025
Boron compounds: boronic and borinic acid compounds
C07D 401/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
C07D 403/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond

Family

Application63/107,818Us provisional application · filed 30 Oct 2020

Application63/192,605Us provisional application · filed 25 May 2021

Application17/515,758Parent of this continuation · filed 1 Nov 2021

US 2024/0352046 A1Pre-grant publication · published 24 Oct 2024

US 2022/0135598 A1Published application

US 12,325,720 B2This patent

From the US filing history. Foreign family members aren’t listed.