Uses of doxadiazines compounds

A cosmetic method for treating thin and dry skin, fine wrinkles, decreased elasticity, aberrant pigmentation, hair graying and hair loss, irradiated skin damage and for skin whitening in a subject comprising:

• administering a compound of formula (I) or a cosmetically acceptable salt, stereoisomer or solvate thereof,
• wherein one Z is N and the other is —C—R2;
• and R2 and R1 are independently selected from the group consisting of H, alkyl and aryl, and
• wherein R is selected from a group consisting of
• a) a linear or branched C1-8 alkyl, a linear or branched C2-8 alkenyl, di-halo methyl, tri-halo methyl, C5-6 cycloalkyl, (C1-6 alkyl)O—CH2—, amine di-substituted with independently selected C1-6 alkyl groups,
• b) phenyl optionally substituted with one or more groups independently selected from C1-8 alkyl, C2-8 alkenyl, halogen, phenyl, C1-6 alkoxy, amine di-substituted with independently selected C1-6 alkyl groups, —NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl,
• c) a 5-6 membered aromatic ring having one or more heteroatoms selected from N, S, and O and being optionally substituted with one or more groups independently selected from:
• C1-8 alkyl, linear or branched C2-8 alkenyl, C5-6 cycloalkyl
• phenyl as defined in b)
• 5-6 membered aromatic ring group
• halogen,
• (C1-6alkyl)OCH2—, C1-6 alkoxy,
• amino di-substituted with C1-6 alkyl groups,
• NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl
• d) a bicyclic ring containing at least one phenyl group and a C5-6 aromatic heterocyclic group having one or more heteroatoms selected from N, S, and O, wherein the phenyl group of said bicyclic ring is optionally substituted with one or more groups independently selected from
• C1-8 alkyl, linear or branched C2-8 alkenyl, C5-6 cycloalkyl
• phenyl as defined in b)
• 5-6 membered aromatic ring group
• halogen,
• (C1-6alkyl)OCH2—, C1-6 alkoxy,
• amino di-substituted with C1-6 alkyl groups,
• NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl, and
• e) —CH(R4)—CH(R5)COOH, wherein R4 is selected from H, NH2, OH and CH2COOH, and wherein R5 is selected from H, NH2, OH and CH2COOH,
• to a subject in need thereof.

A method of inhibition of enzymatic browning in food or beverage comprising:

• contacting said food or beverage with a compound of formula (I) or a salt, stereoisomer or solvate thereof
• wherein one Z is N and the other is —C—R2;
• and R2 and R1 are independently selected from the group consisting of H, alkyl and aryl, and
• wherein R is selected from a group consisting of
• a) a linear or branched C1-8 alkyl, a linear or branched C2-8 alkenyl, di-halo methyl, tri-halo methyl, C3-6 cycloalkyl, (C1-6 alkyl)O—CH2—, amine di-substituted with independently selected C1-6 alkyl groups,
• b) phenyl optionally substituted with one or more groups independently selected from C1-8 alkyl, C2-8 alkenyl, halogen, phenyl, C1-6 alkoxy, amine di-substituted with independently selected C1-6 alkyl groups, —NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl,
• c) a 5-6 membered aromatic ring having one or more heteroatoms selected from N, S, and O and being optionally substituted with one or more groups independently selected from:
• C1-8 alkyl, linear or branched C2-8 alkenyl, C5-6 cycloalkyl
• phenyl as defined in b)
• 5-6 membered aromatic ring group
• halogen,
• (C1-6alkyl)OCH2—, C1-6 alkoxy,
• amino di-substituted with C1-6 alkyl groups,
• NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl
• d) a bicyclic ring containing at least one phenyl group and a C5-6 aromatic heterocyclic group having one or more heteroatoms selected from N, S, and O, wherein the phenyl group of said bicyclic ring is optionally substituted with one or more groups independently selected from
• C1-8 alkyl, linear or branched C2-8 alkenyl, C5-6 cycloalkyl
• phenyl as defined in b)
• 5-6 membered aromatic ring group
• halogen,
• (C1-6alkyl)OCH2—, C1-6 alkoxy,
• amino di-substituted with C1-6 alkyl groups,
• NHC(O)R3—, —C(O)NH—R3, —OC(O)R3, and —C(O)OR3—, wherein R3 is C1-6 alkyl, and
• e) —CH(R4)—CH(R5)COOH, wherein R4 is selected from H, NH2, OH and CH2COOH, and wherein R5 is selected from H, NH2, OH and CH2COOH.