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US 12,325,691 B2Granted
Compounds and methods for treating cancer, neurological disorders, ethanol withdrawal, anxiety, depression, and neuropathic pain
AssigneeBoard of Regents, The University of Texas System
InventorsStephen F. Martin, James J. Sahn, Luisa Scott, Jonathan Thomas Pierce-Shimomura
Life of this patent
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Abstract
Provided herein, inter alia, are compounds and methods of treating diseases including cancer, neurological disease, alcohol withdrawal, depression and anxiety, and neuropathic pain.
Claims8
A compound having the formula:
- wherein:
- R1 is substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
- R2 is —C(O)R4, —S(O)n2R4, heteroatom-substituted alkyl, heteroatom-substituted or unsubstituted heteroalkyl, or heteroatom-substituted cycloalkyl, heteroatom-substituted or unsubstituted heterocycloalkyl;
- n2 is 1 or 2;
- n is 1 or 2;
- and
- R4 is heteroatom-substituted alkyl, heteroatom-substituted or unsubstituted heteroalkyl, heteroatom-substituted cycloalkyl, or heteroatom-substituted or unsubstituted heterocycloalkyl, wherein
- the term “heteroatom-substituted” means that one or more hydrogen atoms on the R2 and R4 chemical groups have been replaced with one or more of the following groups:
- halogen, —CF3, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, or —OCHF2;
- provided that the compound is not a compound of the formula:
7 more elements
Dependencies are inferred from the claim text.