Large pore agarose
AssigneeCytiva BioProcess R&D AB
InventorsDavid Jansson, Jesper Hansson, Anna Akerblom, Emma Michaelsson
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Abstract
The present invention relates to porous cross-linked agarose gel beads which have a low agarose content, a method for the preparation of the beads and their use in chromatographic applications. The beads are suitable for the separation/purification of biomolecules from a biological sample. Due to the high porosity of the beads, they are especially suitable for separation/isolation of larger particles, such as virus particles e.g. adeno virus.
Claims6
Porous spherical cross-linked agarose gel beads, comprising an agarose concentration of about 0.3-0.8% w/v, or a dry weight of about 5-15 mg/mL;
- wherein ligands are attached to the beads, the ligands being quaternary amine ligands, sulphate ligands, virus affinity ligands and/or multimodal ligands.
Dependencies are inferred from the claim text.