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US 12,324,859 B2Granted
Compounds and compositions for intracellular delivery of therapeutic agents
AssigneeModernaTX, Inc.
InventorsKerry E. Benenato, Ellalahewage Sathyajith Kumarasinghe, Mark Cornebise
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Abstract
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Claims11
A compound of Formula (IA):
- or its N-oxide, or a salt or isomer thereof, wherein
- l is selected from 1, 2, 3, 4, and 5;
- m is selected from 5, 6, 7, 8, and 9;
- M1 is a bond or M′;
- R4 is
- M and M′ are independently selected from —C(O)O— and —OC(O)—;
- R2 and R3 are independently selected from the group consisting of C6-9 alkyl and C6-9 alkenyl;
- and
- R′ is
6 more elements
Dependencies are inferred from the claim text.