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US 12,324,842 B2Granted
Compositions and methods for making antibody conjugates
AssigneeThe Trustees of the University of Pennsylvania
InventorsAndrew Tsourkas, James Z Hui
Life of this patent
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Abstract
The invention relates to antibody conjugates (e.g., a bispecific antibody), drug and nanoparticle compositions and methods and compositions for generating them. This invention further relates to methods of using these compositions for imaging, diagnosing or treating a disease.
Claims16
An adapter comprising an antibody binding domain (AbBD), wherein the AbBD is a variant of a Protein G subdomain comprising an amino acid sequence with at least 80% identity to the sequence set forth in SEQ ID NO:
- 2 and having a photo-reactive amino acid replacement and/or photo-reactive amino acid modification at A24, K28 or both of the sequence with at least 80% identity to the sequence set forth in SEQ ID NO:
- 2, and wherein the AbBD specifically binds and crosslinks to an immunoglobulin.
Dependencies are inferred from the claim text.