Application of heptoglycan-chain-containing oligosaccharide compounds in preparation of vaccine against Helicobacter pylori

Abstract

Disclosed is the application of heptoglycan-chain-containing oligosaccharide compounds in preparation of a vaccine against Helicobacter pylori, belonging to the field of medicine. Different antigen oligosaccharides were obtained by chemical synthesis and fixed onto a chip surface to prepare a synthetic oligosaccharide chip. With animal immunization experiments and synthetic oligosaccharide chip analysis, the antibodies in antiserum produced by Helicobacter pylori polysaccharide immunization are used to determine the structure-activity relationship between the synthetic oligosaccharides and immunogenicity. It is found that the heptoglycan chain in the oligosaccharide compounds is an important immune epitope, and oligosaccharides containing α-(1→3) heptoglycan chain can be used in preparation and development of vaccines for prevention and treatment of Helicobacter pylori infection.

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