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US 12,324,818 B2Granted
Generation of alveolar epithelial type 1 (AT1) cells
AssigneeTrustees of Boston University
InventorsClaire Burgess, Darrell Kotton
Life of this patent
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Abstract
The technology described herein is directed to methods of producing or differentiating AT1 cells, and AT1 cells made by the methods described herein.
Claims13
A method comprising culturing at least one alveolar epithelial cell type II (AT2) cell and/or lung epithelial progenitor cell in a medium comprising a Large Tumor Suppressor Kinase (LATS) inhibitor;
- wherein said culturing results in the differentiation of the at least one AT2 cell and/or lung epithelial progenitor cell to an alveolar epithelial cell type I (AT1) cell.
Dependencies are inferred from the claim text.