Glucopyranosyl derivatives and their uses

A compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a pharmaceutically acceptable salt, a dimer, or a trimer thereof,

• wherein,
• Y is —(CH2)q—, —O—, —NH—, —S—, —S (═O)— or —S (═O)2—;
• q is 0, 1, 2 or 3;
• L is C1-6 alkylene or C1-6 alkenylene, wherein the L is unsubstituted or substituted with 1, 2 or 3 Ry;
• R1 is H, deuterium, F, Cl, Br, I, —OH, —CN, —NO2, —NH2, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 alkylthio, cyano C1-6 alkyl, amino C1-6 alkyl, hydroxy C1-6 alkyl or C3-6 cycloalkyl;
• each of R5 and R6 is independently H, deuterium, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, 5-6 membered heterocyclyl, C6-10 aryl or 5-6 membered heteroaryl;
• or R5, R6 together with the nitrogen atom they are attached to, form a 5-6 membered heterocyclic ring or a 5-6 membered heteroaromatic ring;
• R4 is F, Cl, Br, I, OH, CN, NO2, NH2, —SH, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 alkylamino, hydroxy C1-6 alkyl, cyano C1-6 alkyl, amino C1-6 alkyl, C3-6 cycloalkyl, 5-6 membered heterocyclyl, C6-10 aryl or 5-6 membered heteroaryl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylthio, C1-6 alkylamino, hydroxy C1-6 alkyl, cyano C1-6 alkyl, amino C1-6 alkyl, C3-6 cycloalkyl, 5-6 membered heterocyclyl, C6-10 aryl or 5-6 membered heteroaryl is independently unsubstituted or substituted with 1, 2 or 3 Rx;
• each of R2 and R3 is independently H, deuterium, F, Cl, Br, I, OH, CN, NO2, NH2, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkylamino, C1-6 alkylthio, hydroxy C1-6 alkyl, cyano C1-6 alkyl, or amino C1-6 alkyl;
• or R2, R3 together with
• they are attached to, form
• wherein the bond to the R2 group is identified by *, and the bond to the R3 group is identified by **;
• each of R7 and R8 is independently H, deuterium, F, Cl, Br, I, OH, CN, NO2, NH2, —SH, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkyl, C1-6 haloalkoxy, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl, wherein each of the C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino, C1-6 haloalkyl, C1-6 haloalkoxy, C3-8 cycloalkyl, 3-8 membered heterocyclyl, C6-10 aryl or 5-8 membered heteroaryl is independently unsubstituted or substituted with 1, 2 or 3 Rw;
• or R7, R8 and the carbon atom to which they are attached form a C3-8 carbocyclic ring or a 3-8 membered heterocyclic ring, wherein each of the C3-8 carbocyclic ring and 3-8 membered heterocyclic ring is independently unsubstituted or substituted with 1, 2 or 3 Rw;
• each Rx, Ry, and Rw is independently deuterium, F, Cl, Br, I, CN, NO2, OH, NH2, —SH, ═O, —C (═O) OH, —C(═O)NH2, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 haloalkoxy;
• wherein, the compound does not include