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US 12,322,584 B2Granted
Apparatus and methods for detection and quantification of elements in molecules
AssigneeGeorgetown University
InventorsKaveh Jorabchi, Joseph Lesniewski, Kunyu Zheng, Samuel White
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Abstract
A method that includes introducing at least one analyte into a gas plasma; generating neutral species from atoms of the analyte in the gas plasma; preferentially transporting the neutral species downstream of the gas plasma relative to any ions produced in the gas plasma; and reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source.
Claims20
A method comprising;
- introducing at least one analyte into a gas plasma;
- generating neutral species from atoms of the analyte in the gas plasma;
- transporting the neutral species downstream of the gas plasma;
- and
- reacting the neutral species of the analyte with at least one reagent ion downstream of the plasma resulting in ion species of the analyte, wherein the at least one reagent ion is supplied by an independent ion source.
2 more elements
An apparatus comprising:
- a gas plasma module;
- an ion source downstream from the gas plasma module, wherein the ion source is an electrospray ionization module or a corona discharge module;
- and
- a mass spectrometer downstream from the ion source.
1 more element
Dependencies are inferred from the claim text.