Insulated serial column chromatography arrangements and systems

A chromatography columns arrangement, comprising:

• a plurality of chromatography columns arranged in a longitudinally parallel cluster configuration;
• a single insulating sleeve which collectively encompasses the chromatography columns in the cluster configuration and provides thermal management of the chromatography columns;
• first and second end caps for the chromatography columns arrangements, the endcaps being sized to encompass the plurality of chromatography columns and to interface with the single insulating sleeve to form a sealed container;
• an inlet valve for directing mobile phase with a sample of analyte into the cluster configuration, the inlet valve interfaces with the insulating sleeve and integrated into the first end cap for the arrangement;
• an outlet valve for directing the mobile phase with the sample of analyte from a selected one of the chromatography columns to an output, the outlet valve interfaces with the insulating sleeve and integrated into the second end cap for the arrangement;
• a controller configured for controlling the inlet valve and the outlet valve to serially pass the mobile phase with the sample of analyte through multiple successive ones of the plurality of a sequence of successive ones of the chromatography columns.