Use of mutant of immunoglobulin degrading enzyme IdeE
AssigneeShanghai Bao Pharmaceuticals Co., Ltd.
InventorsYanjun Liu, Zheng Wang, Zhen Zhu, Lin Lu
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Abstract
Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein comprising the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.
Claims14
A mutant of an immunoglobulin degrading enzyme IdeE, wherein an amino acid sequence of the immunoglobulin degrading enzyme IdeE is shown as SEQ ID NO:
- 2:
- the mutant comprises a mutation of a truncation of the immunoglobulin degrading enzyme IdeE, by deleting the sequence of the first 15, the first 16, the first 17, the first 18 or the first 19 amino acids at the N-terminus;
- and
- the mutant comprises the amino acid sequence shown as SEQ ID NO:
- 36.
Dependencies are inferred from the claim text.