Body fluid resistant tissue adhesives
AssigneesMassachusetts Institute of Technology, Mayo Foundation for Medical Education and Research
InventorsXuanhe Zhao, Hyunwoo Yuk, Xinyu Mao, Christoph Nabzdyk
Life of this patent
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Abstract
A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
Claims20
A method of adhering one or more tissue surfaces covered in one or more fluids comprising:
- (a) applying an adhesive material directly to one or more of the fluid covered tissue surfaces, the adhesive material comprising:
- a hydrophobic matrix;
- and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix, the bioadhesive microparticles comprising:
- (i) one or more hydrophilic polymers or copolymers;
- (ii) one or more amine coupling groups, and (iii) one or more cross linkers;
- (b) applying pressure ranging from about 1 kPa to 50 kPa to the adhesive material;
- (c) allowing the hydrophobic matrix to repel and clean the one or more fluids from the tissue surfaces;
- (d) allowing physical bond forming group in the bioadhesive microparticles to form temporary crosslinks by intermolecular bonds;
- and
- (e) allowing amine coupling groups in the bioadhesive microparticles to form covalent crosslinks with the tissue surfaces.
A method of healing a tissue injury comprising:
- (a) applying an adhesive material directly to the tissue injury, wherein the tissue injury comprises one or more fluid covered tissue surfaces, the adhesive material comprising:
- a hydrophobic matrix;
- and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix, the bioadhesive microparticles comprising:
- (i) one or more hydrophilic polymers or copolymers;
- (ii) one or more amine coupling groups, and (iii) one or more cross linkers;
- (b) applying pressure ranging from about 1 kPa to 50 kPa to the adhesive material;
- (c) allowing the hydrophobic matrix to repel and clean the one or more fluids from the tissue surfaces;
- (d) allowing physical bond forming group in the bioadhesive microparticles to form temporary crosslinks by intermolecular bonds;
- (e) allowing amine coupling groups in the bioadhesive microparticles to form covalent crosslinks with the tissue surfaces;
- and
- (f) allowing cell infiltration into the crosslinked bioadhesive microparticles and healing of the underlying tissue injury.
Dependencies are inferred from the claim text.