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US 12,319,752 B2Granted
Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria
AssigneeNortheastern University
InventorsRun Chang, Keerthana Subramanian, Mian Wang, Thomas J. Webster
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Abstract
Disclosed are peptides comprising an amphiphilic backbone and a cationic heparin-binding motif peptide. The peptides can be used in methods of antimicrobial treatment.
Claims13
A method of preventing or suppressing growth of a bacterium on a surface, comprising:
- applying to the surface a plurality of polypeptides represented by:
- R1-y1-y2
- wherein
- R1-y1 is an amphiphilic backbone;
- y2 is a cationic heparin-binding Cardin motif peptide;
- R1 is an alkyl group or an alkenyl group;
- and
- y1 has the sequence V4K4 (SEQ ID NO:
- 1) or V4K4G (SEQ ID NO:
- 4)
- thereby preventing or suppressing growth of the bacterium on the surface.
8 more elements
Dependencies are inferred from the claim text.