Human monoclonal antibody human CD134 (OX40) and methods of making and using same
AssigneeKyowa Kirin Co., Ltd.
InventorsShinichiro Kato, Rachel Soloff Nugent, Hitoshi Yoshida, Michael Croft
Life of this patent
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Abstract
The invention provides antibodies that specifically bind to OX40 (CD134), referred to as OX40 antibodies, anti-OX40 or anti-OX40 antibodies. Invention antibodies that specifically bind to OX40 include mammalian (human, primate, etc.), humanized and chimeric anti-OX40 antibodies. Invention antibodies and antibody subsequences (fragments) that specifically bind to OX40 include purified and isolated antibodies, as well as pharmaceutical formulations thereof, are useful in various methods including treatment, screening and detection methods.
Claims17
A monoclonal antibody, wherein the monoclonal antibody comprises:
- a heavy chain comprising an amino acid sequence from the amino acid at position 20 of SEQ ID NO:9 to the amino acid at position 141 of SEQ ID NO:9,
- and a light chain comprising an amino acid sequence from the amino acid at position 21 of SEQ ID NO:10 to the amino acid at position 129 of SEQ ID NO:10.
A pharmaceutical composition comprising a monoclonal antibody and a pharmaceutically acceptable carrier, diluent or excipient, wherein the monoclonal antibody comprises:
- a heavy chain comprising an amino acid sequence from the amino acid at position 20 of SEQ ID NO:9 to the amino acid at position 141 of SEQ ID NO:9,
- and a light chain comprising an amino acid sequence from the amino acid at position 21 of SEQ ID NO:10 to the amino acid at position 129 of SEQ ID NO:10.
A method of treating Atopic Dermatitis, comprising administering to a subject in need thereof a monoclonal antibody, wherein the monoclonal antibody comprises:
- a heavy chain comprising an amino acid sequence from the amino acid at position 20 of SEQ ID NO:9 to the amino acid at position 141 of SEQ ID NO:9,
- and a light chain comprising an amino acid sequence from the amino acid at position 21 of SEQ ID NO:10 to the amino acid at position 129 of SEQ ID NO:10.
A method of treating asthma, comprising administering to a subject in need thereof a monoclonal antibody, wherein the monoclonal antibody comprises:
- a heavy chain comprising an amino acid sequence from the amino acid at position 20 of SEQ ID NO:9 to the amino acid at position 141 of SEQ ID NO:9,
- and a light chain comprising an amino acid sequence from the amino acid at position 21 of SEQ ID NO:10 to the amino acid at position 129 of SEQ ID NO:10.
Dependencies are inferred from the claim text.