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US 12,319,721 B2Granted
Targeting anabolic drugs for accelerated fracture repair
AssigneePurdue Research Foundation
InventorsPhilip Stewart Low, Stewart A. Low, Jeffery Jay Howard Nielsen
Life of this patent
Estimating the term…
Abstract
The targeted delivery of growth factors, vasoactive peptides and other representative anabolic peptide drugs from different signaling cascades to bone fracture for accelerated healing is disclosed herein.
Claims16
A compound having a structure of:
- X-Y-Z
- wherein:
- X comprises a fibroblast growth factor (FGF) receptor targeting sequence;
- Y is a releasable linker;
- and
- Z is a bone-targeting molecule,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound having a structure of:
- X-Y-Z
- wherein:
- X comprises a fibroblast growth factor (FGF) receptor targeting sequence;
- Y comprises mp4;
- and
- Z is a bone-targeting molecule,
- or a pharmaceutically acceptable salt thereof.
4 more elements
A compound having a structure represented by
- (SEQ ID NOS:
- 28, 32, and 45).
Dependencies are inferred from the claim text.