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US 12,319,710 B2Granted
Catecholamine prodrugs for use in the treatment of Parkinson's diseases
AssigneeH. Lundbeck A/S
InventorsMorten Jørgensen, Martin Juhl, Klaus Gjervig Jensen
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Abstract
The present invention provides compounds of formula (Id) that are prodrugs of catecholamine for use in treatment of neurodegenerative diseases and disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating neurodegenerative or neuropsychiatric diseases and disorders using the compounds of the invention, in particular Parkinson's disease.
Claims29
A compound according to formula (Id)
- wherein R1 and R2 are defined according to a) to c) below:
- a) R1 is selected from H, C1-C6 alkyl, benzyl and linear-C(O) C1-C6 alkyl and R2 is substituent (i) below;
- or
- b) R1 is substituent (i) below and R2 is selected from H, C1-C6 alkyl, benzyl and linear-C(O) C1-C6 alkyl;
- or
- c) R1 and R2 are both represented by substituent (i) below
- and
- wherein R3 is selected from H and —C(O) C1-C6 alkyl;
- and
- wherein * indicates the attachment point;
- and
- wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration;
- with the proviso that when one of R1 or R2 is substituent (i) and R3 is H then the other of R1 or R2 cannot be linear-C(O) C1-C6 alkyl;
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.