Heterocyclic nitrogen-containing purine derivatives, pharmaceutical preparations containing these derivatives and their use in neuroprotection
AssigneesUniverzita Palackeho, Fakultni Nemocnice Olomouc
InventorsGabriel Gonzales, Vaclav Mik, Noemi Bucharova, Jiri Gruz, Petr Kanovsky, Miroslav Strnad, Marek Zatloukal
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Abstract
Heterocyclic nitrogen-containing purine derivatives and their use in the medicinal applications and compositions containing these derivatives is disclosed. A new generation of compounds possessing selective antineurodegenerative properties on neuronal cells and tissues and that can be particularly used in the treatment and prophylaxis of neurodegenerative disease, particularly in the treatment and prophylaxis of Parkinson's disease is also disclosed.
Claims9
Heterocyclic nitrogen-containing purine derivative of the general formula I,
- wherein
- R are independently selected from the group consisting of H, Cl, Br, methyl, OH, and methoxy, and n=1 or 2;
- R1 is independently on each occurrence H or methyl, or R1 is not present;
- A is independently on each occurrence selected from the group consisting of C, N S;
- a, b, c, d are, independently of each other, an integer selected from 1, 2, 3;
- provided that the compound of formula I is not 2,6-dimorpholino-9-benzylpurine;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.