Lipid compound containing carbamate bond and applications thereof
AssigneeRongcan (Shanghai) Biotech Co., Ltd.
InventorsXueqing Zhang, Yilong Teng, Bin Zhang, Xing Zheng
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Abstract
The present invention belongs to the field of biomedicine, which discloses a class of lipid compounds containing carbamate bond and applications thereof. The lipid compounds have the following structures: wherein the definitions of the various groups are described in the specification. The lipid nanoparticulate carriers prepared from the compounds described in the present invention exhibit excellent biocompatibility and safety as well as unexpected improvements in transfection efficiency, making them suitable for biomedical industrialization.
Claims14
A lipid compound having a structure of Formula:
- wherein:
- n1 and n2 are each independently 0, 1, or 2;
- G1 and G2 are each independently C4-C8 alkylene;
- R1, R2, R3 and R4 are each independently C1-C12 linear or branched alkyl, or C2-C10 linear or branched alkenyl;
- G3 is C2-C5 alkylene;
- or G3 is (CH2)a—O—(CH2)b, wherein a and b are each independently 2;
- L1 is —(C═O)O—, —O(C═O)—, or —O(C═O)O—;
- L2 is —NH(C═O)O— or —O(C═O)NH—.
Dependencies are inferred from the claim text.