GHz-THz ultrasonics and optics for neurotechnology devices, methods, and applications

A neuro-cognitive system, comprising:

• an implantable device, the implantable device including:
• a substrate having a first surface and a second surface opposite the first surface;
• a cellular interaction region disposed at or in the first surface of the substrate;
• a CMOS chip disposed adjacent the second surface of the substrate, the CMOS chip comprising a plurality of transducers, the plurality of transducers comprising a first plurality of transducers to transmit phased ultrasonic beams through the substrate toward the cellular interaction region to interrogate, to impart energy to, or to activate, in vivo, one or more cells or one or more biological structures at or adjacent the cellular interaction region and further comprising a second plurality of transducers to receive return signals from the one or more cells or one or more biological structures at or adjacent the cellular interaction region responsive to the transmitted phased ultrasonic beams;
• and
• an electrode electrically connected to the cellular interaction region.

A method for reading an electrical output of one or more cellular interaction regions of one or more implantable devices, comprising the steps of:

• disposing a signaling unit comprising a first wireless communication device adjacent the skin of a subject within a wireless coupling range of a second wireless communication device of a first implanted implantable device of the one or more implanted implantable devices, the first implanted implantable device comprising the second wireless communication device, a substrate having a first surface and a second surface opposite the first surface, a cellular interaction region disposed at or in the first surface of the substrate, an electrode electrically connected to the cellular interaction region, a CMOS chip disposed adjacent the second surface of the substrate, the CMOS chip comprising a plurality of transducers, the plurality of transducers comprising a first plurality of transducers configured to transmit phased ultrasonic pulses with a frequency between about 1-200 GHz through the substrate toward the cellular interaction region of the first implanted implantable device to interrogate, to impart energy to, or to activate or more cells or one or more biological structures at or adjacent the cellular interaction region and further comprising a second plurality of transducers configured to receive return signals from the one or more cells or one or more biological structures at or adjacent the cellular interaction region responsive to the transmitted phased ultrasonic pulses;
• wirelessly connecting the first wireless communication device of the signaling unit to the second wireless communication device of the first implanted implantable device;
• and
• outputting a signal from the first wireless communication device of the signaling unit to the second wireless communication device of the first implanted implantable device to cause one or more of the plurality of transducers of the CMOS chip to output one or more ultrasonic pulses with a frequency between about 1-200 GHz toward the cellular interaction region of the first implanted implantable device.