# US 12,318,635 B2 · Apparatus and method for treating kidneys > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,318,635 B2 - Document ID: US12318635B2 - Status: Granted - Kind: B2 - Application number: 17/282,390 - Filed: 2019-10-03 - Published: 2021-11-11 - Granted: 2025-06-03 - Earliest claimed: 2018-10-03 - Assignees: MDSG Innovation Ltd. - Applicants: MDSG Innovation Ltd. - Inventors: Benny Rousso; Naama Winetraub; Boaz Rippin; Lior Eshel; Assaf Erell; Rodny Zarini - Web page: https://patentgrep.com/patent/US12318635B2 ## CPC - A61B 8/085: {for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules} - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61N 7/02: Localised ultrasound hyperthermia - A61B 2017/00699: {correcting for movement caused by respiration, e.g. by triggering} - A61B 2018/00511: {Kidney} - A61N 2007/0004: {Applications of ultrasound therapy} - A61N 2007/0047: {interstitial} - A61N 2007/006: {Lenses} - A61N 2007/0078: {with multiple treatment transducers} - A61N 2007/0095: {by modifying an excitation signal} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract The present invention relates to means and methods for modifying renal function in a subject, comprising selecting a patient requiring an increment in renal function; emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a period of time from about 1 hours to about 30 days. ## Claims ### Claim 1 A method for modifying renal function, comprising: a. selecting a patient requiring an increment in renal function; b. emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a treatment period of time from about 1 hour to about 30 days; c. monitoring temperature at skin or tissue, said monitoring is at multiple interface locations to manage ultrasound power distribution; wherein said ultrasound radiation is characterized by having a pulse frequency from about 3 MHz to about 15 MHz and a duration from about 0.2 μsec to about 10 μsec; and wherein said emitting comprises achieving renal function modification while avoiding inducing thermal adverse effects. ### Claim 2 (depends on 1) The method according to claim 1, wherein said ultrasound radiation is characterized by individual emission pulses having an amplitude of less than 2 MPa. ### Claim 3 (depends on 1) The method according to claim 1, wherein said ultrasound radiation is characterized by a pulse repetition rate from about 0.1 kHz to about 30 kHz. ### Claim 4 (depends on 1) The method according to claim 1, wherein said emitting ultrasound radiation comprises emitting said ultrasound radiation between ribs. ### Claim 5 (depends on 1) The method according to claim 1, wherein said emitting ultrasound radiation comprises emitting said ultrasound radiation over an area of skin. ### Claim 6 (depends on 1) The method according to claim 1, further comprising positioning an ultrasound emission device in one or more locations selected from the group consisting of back, sides, under thorax and over thorax. ### Claim 7 (depends on 1) The method according to claim 1, wherein said ultrasound radiation is characterized by having high frequency higher than 3 MHz and a duration from 0.2 μsec to 10 μsec. ### Claim 8 (depends on 1) The method according to claim 1, further comprising achieving renal function modification while avoiding inducing cavitation adverse effects. ### Claim 9 (depends on 1) The method according to claim 1, further comprising not using ultrasound contrast agent or any other injected material that, when exposed to ultrasonic radiations, a characteristic of said contrast agent or any other injected material is modified. ### Claim 10 (depends on 1) The method according to claim 1, wherein said emitting is repeated for a period of time selected from the group consisting of at least a day, at least 3 days, at least a week, at least a month and at least 2 months. ### Claim 11 (depends on 1) The method according to claim 1, wherein said emitting is applied intermittently for repetitive periods of time selected from a group consisting of: at least 5 minutes each, at least 10 minutes each, at least 15 minutes each and at least 20 minutes each. ### Claim 12 (depends on 1) The method according to claim 1, wherein said emitting further comprises emitting for preventing acute kidney dysfunction. ### Claim 13 (depends on 1) The method according to claim 1, wherein said emitting further comprises emitting for treating symptoms of heart failure in said patient. ### Claim 14 (depends on 1) The method according to claim 1, wherein said emitting comprises not to cause cavitation in the tissue. ### Claim 15 (depends on 1) The method according to claim 1, further comprising monitoring cavitation at skin or tissue, said monitoring is at multiple interface locations to manage ultrasound power distribution. ### Claim 16 (depends on 1) The method according to claim 1, further comprising monitoring mechanical index at skin or tissue to be lower than 1. ### Claim 17 A system for modifying renal function, comprising: a. a plurality of transducer elements; b. circuitry comprising instructions for: i. emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a treatment period of time from about 1 hour to about 30 days; ii. monitoring temperature at skin or tissue, said monitoring is at multiple interface locations to manage ultrasound power distribution; wherein said ultrasound radiation is characterized by having a pulse frequency from about 3 MHz to about 15 MHz and a duration from about 0.2 μsec to about 10 μsec; and wherein said emitting comprises achieving renal function modification while avoiding inducing thermal adverse effects.