Compositions for treatment of discogenic pain, and processes for making and using the same
Assignee33 Medical, Inc.
InventorsEric Olson, Jeff Zisselman, Nick Manesis, Richard Wesley Sierk, III
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Abstract
Compositions for treatment of discogenic pain are discussed herein. In various embodiments, the composition includes PMMA microparticles, Pluronic® surfactant, PBS, and a radio marker. In some embodiments, the PMMA microparticles have a particle size distribution between 25-125 microns and are nonlinearly cross-linked. The composition may be stored at a cooled temperature and upon injection, the composition warms and transitions to a gel state. The composition may also include about 50% PMMA microparticles, about 10% Pluronic®, about 30% PBS, and about 10% of a radio marker.
Claims26
A composition of matter comprising:
- about 30-60% poly (methyl methacrylate) (PMMA) microparticles;
- about 8-25% poloxamer surfactant;
- about 19-49% phosphate buffered saline (PBS);
- and
- about 8-14% of a radio marker, wherein the PMMA microparticles have a particle size distribution between about 25-125 microns and are nonlinearly cross-linked.
A composition of matter comprising:
- about 30-60% poly (methyl methacrylate) (PMMA) microparticles;
- about 8-25% of a hydrogel;
- about 19-49% phosphate buffered saline (PBS);
- and
- about 8-14% of a radio marker, wherein the PMMA microparticles have a particle size distribution between about 25-125 microns and are nonlinearly cross-linked.
A method of making a composition of matter, wherein the composition comprises about 8-25% poloxamer surfactant, about 19-49% PBS, about 8-14% of the radio marker, and about 30-60% PMMA microparticles, the method comprising the steps of:
- mixing PBS, poloxamer surfactant, and a radio marker to form a carrier solution;
- mixing a plurality of nonlinearly cross-linked PMMA microparticles, wherein the PMMA microparticles have a particle size distribution of about 25-125 microns, into the carrier solution;
- chilling the composition to about 3-8° C.;
- adding the composition to a vial;
- sealing the vial;
- sterilizing the vial;
- and
- storing the sterilized vial at about 3-8° C.
A method of treating discogenic pain comprising the steps of:
- storing, at about 3-8° C., a vial having a cap, wherein the vial contains a composition, the composition comprising:
- about 30-60% poly (methyl methacrylate) (PMMA) microparticles;
- about 8-25% hydrogel;
- about 19-49% phosphate buffered saline (PBS);
- and
- about 8-14% of a radio marker, wherein the PMMA microparticles have a particle size distribution between about 25-125 microns and are nonlinearly cross-linked;
- removing the vial from storage;
- mixing the composition;
- removing the cap from the vial;
- attaching a cannula onto a syringe, the syringe having a plunger;
- inserting the cannula into the vial;
- withdrawing the composition from the vial into the syringe;
- attaching a spinal needle to the syringe, the spinal needle including a stopcock, wherein the stopcock is in an open position when it is attached to the syringe;
- remove any entrapped air from the spinal needle by ejecting a small amount of the composition from the syringe through the spinal needle;
- inserting the spinal needle into an intervertebral disc of a patient;
- injecting the composition into the intervertebral disc of the patient;
- upon fully injecting the composition into the intervertebral disc of the patient, moving the stopcock to a closed position;
- removing the syringe from the stopcock;
- allowing the composition to transition from a liquid to a gel as the composition increases in temperature;
- and
- upon gelation of the composition within the intervertebral disc of the patient, remove the spinal needle from the patient.
Dependencies are inferred from the claim text.