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US 12,318,462 B2Granted
Multi-coated nanoparticles comprising multiple coating layers of chitosan and polyglutamic acid, composition for skin care comprising the same and method for manufacturing the same
AssigneeBinotec Co., Ltd.
InventorsYu-Mi Kim, Gi-Hyun Jang
Life of this patent
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Abstract
Multi-coated nanoparticles including multiple coating layers of chitosan and polyglutamic acid, composition for skin care including the same, and method of manufacturing the same are provided. The nanoparticles have a liposome core layer and coating layers. The core layer includes a bioactive particle and a core hydrogel. Not only is it easy to mass-produce, but also has the effect of steadily releasing bioactive particles for a long period of time due to its high sealing rate and high stability.
Claims12
A multi-coated nanoparticle comprising:
- a liposome core layer comprising a bioactive particle and a core hydrogel having a charge opposite to a charge of the bioactive particle, the liposome core layer that is surrounded by a phospholipid bilayer;
- a first coating layer consisting of chitosan of 0.05 wt % to 0.15 wt % with respect to a total weight of the nanoparticle, the first coating layer located on the core layer;
- a second coating layer consisting of polyglutamic acid of 0.06 wt % to 0.15 wt % with respect to the total weight of the nanoparticle, the second coating layer located on the first coating layer;
- and
- a third coating layer consisting of chitosan of 0.005 wt % to 0.03 wt % with respect to the total weight of the nanoparticle, the third coating layer located on the second coating layer,
- wherein the volume ratio of the first coating layer and the second coating layer is 1:0.0001 to 1:10, and wherein a size of the multi-coated nanoparticle is about 150 nm to 400 nm.
3 more elements
A composition for skin care comprising:
- multi-coated nanoparticles;
- and
- purified water that is configured to contain the multi-coated nanoparticles;
- and wherein at least one of the multi-coated nanoparticles comprises:
- a liposome core layer comprising a bioactive particle and a core hydrogel, the liposome core layer that is surrounded by a phospholipid bilayer;
- a first coating layer consisting of chitosan of 0.05 wt % to 0.15 wt % with respect to a total weight of the nanoparticle;
- a second coating layer consisting of polyglutamic acid of 0.06 wt % to 0.15 wt % with respect to the total weight of the nanoparticle;
- a third coating layer consisting of chitosan of 0.005 wt % to 0.03 wt % with respect to the total weight of the nanoparticle, and
- wherein the core hydrogel is configured to electrostatically bind to the bioactive particle,
- wherein the volume ratio of the first coating layer and the second coating layer is 1:0.0001 to 1:10, and
- wherein a size of the multi-coated nanoparticle is 150 nm to 400 nm.
8 more elements
Dependencies are inferred from the claim text.