VLP stabilized vaccine compositions
AssigneeInventprise, LLC
InventorSubhash V. Kapre
Life of this patent
Estimating the term…
Abstract
The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.
Claims47
A process for the manufacture of a liquid composition comprising virus-like particles (VLPs), an immunogenic component, and a stabilizing agent comprising:
- providing VLPs;
- providing an immunogenic portion of a bacterium as the immunogenic component;
- providing one or more degraded gelatins as the stabilizing agent, wherein the one or more gelatins are degraded to an average molecular weight of twenty kilodaltons or less;
- combining the VLPs, the immunogenic component, and the stabilizing agent;
- and
- forming the liquid composition, wherein the composition has not been maintained in a non-liquid state and is maintained as a liquid prior to administration.
A method for the manufacture of a composition comprised of VLPs, an immunogenic component, and a stabilizing agent, comprising:
- generating VLPs comprising structural components of hepatitis virus particles;
- providing an immunogenic portion of a bacterium as the immunogenic component;
- providing a stabilizing agent comprised of degraded gelatin;
- mixing the VLPs, the immunogenic component and the stabilizing agent, wherein structural components, the immunogenic component and the stabilizing agent are mixed at approximately equimolar amounts;
- and
- forming an aqueous composition of the mixture, wherein the composition has not been maintained in a non-liquid state and is maintained as a liquid prior to administration.
A method for the manufacture of a composition comprised of VLPs, an immunogenic component, and a stabilizing agent, comprising:
- generating VLPs comprising structural components of papilloma virus particles;
- providing an immunogenic portion of a bacterium as the immunogenic component;
- providing a stabilizing agent comprised of degraded gelatin;
- mixing the VLPs, the immunogenic component and the stabilizing agent, wherein structural components, the immunogenic component and the stabilizing agent are mixed at approximately equimolar amounts;
- and
- forming an aqueous composition of the mixture, wherein the composition has not been maintained in a non-liquid state and is maintained as a liquid prior to administration.
Dependencies are inferred from the claim text.