Attenuating viral mutations in protein genes
AssigneeBoard of Regents, The University of Texas System
InventorsJaclyn Kaiser, Tian Wang, Alan Barrett, Kassandra Carpio
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Abstract
Embodiments relate to attenuated flaviviruses for use in vaccines and immunogenic compositions. Embodiments include methods for treating or preventing one or more conditions, for example flavivirus infection, using an attenuated flavivirus. In some embodiments, the provided methods and compositions involve one or more attenuated flaviviruses that are capable of inducing a protective immune response.
Claims19
An attenuated flavivirus genome comprising a NS4B gene segment encoding a mutant NS4B protein having an amino acid substitution analogous to an alanine or glycine substitution at proline 54 of the West Nile Virus (WNV) NS4B protein, SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.